Calibrate doctors prescribe medications called GLP-1s (glucagon-like peptide-1s) because research shows that, in combination with coaching, GLP-1s are the most effective and safe long-term option for weight loss.

"Calibrate's platform makes it easier to lose weight by combining proven medications with coaching and information."

Randy Seeley, Ph.D.

Calibrate Clinical Advisor

Professor of Surgery, Director, Michigan Nutrition Obesity Research Center



In your body, GLP-1s are powerful hormones made by your gut that send signals to your brain to decrease your appetite, improve your metabolic function, and regulate your digestion so you can feel full longer and maximize nutrient absorption. Research suggests that people who hold onto more weight experience reductions in GLP-1 signaling. 

The GLP-1 medications that Calibrate doctors prescribe work on the same receptors as your natural GLP-1 hormones. Originally developed to treat type 2 diabetes, the FDA has approved the use of a brand of GLP-1s for weight loss in people without type 2 diabetes.

The Key To

A Metabolic Reset.

GLP-1s are wide-reaching hormones that work in several parts of the body to influence everything from blood pressure to inflammation. By improving your overall metabolic health, they lower your set point, which is the weight your body will fight to stay at. In this way, the GLP-1 medications available today can help you reduce your body weight by 10%. 

We expect Calibrate members to stay on GLP-1 medication for at least six months, and your health and biology will determine the ultimate duration of medication for you. Over the course of your Calibrate year, the habit changes you will make across food, sleep, exercise, and emotional health will help ensure that your success is locked in once the Calibrate medical team determines that you are ready to transition off of medication.


When you join Calibrate, you’ll complete a comprehensive health intake, including blood work, that your Calibrate doctor will carefully review before customizing your treatment plan and prescribing your medication. 

In your first video appointment, your doctor will review your intake with you, prescribe your medication, provide instructions for how to take it, and answer any questions you have. 

The Calibrate medical team is always available in the Medical Channel in the app to support you as you begin your medication and throughout your Calibrate year.

The Right Coverage

For Your Prescription.

Our Support team will work directly with your commercial or employer insurance to make sure your medication costs you $25 or less per month. They’re also available in the app to help answer any questions you have about medication coverage or refills.   

While rare, if you're in any way unsatisfied with your insurance plan’s coverage of your medications, we can end your program and issue a refund before you fill your first month’s medication. See our refund policy for full details.

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