Calibrate doctors prescribe GLP-1 medications because research shows, in combination with 1:1 video coaching and small lifestyle changes, they are the safest and most effective long-term option for weight loss.
GLP-1s are different from older classes of prescription weight loss medications (like phentermine) because they work on key underlying metabolic pathways to support sustained weight loss. They're not just another quick fix. Calibrate doctors prescribe a variety of GLP-1 medications, including semaglutide and liraglutide, which you may know under brand names like Wegovy®, Saxenda®, Ozempic®, or Mounjaro®.
GLP-1s are clinically proven to reduce inflammation markers, leading to decreased inflammatory response and oxidative stress. CRP (C-reactive protein), a general inflammatory marker, is one marker we may follow during your Metabolic Reset.
SHIFT SET POINT
GLP-1s aid in shifting your body’s set point (the weight your body fights to maintain) by impacting areas in the brain—to help curb cravings, make you feel full faster, and increase your energy expenditure.
GLP-1s slow how quickly food moves from the stomach to the intestines. This helps you feel full for longer by regulating sugar absorption in the intestine.
IMPROVE METABOLIC FUNCTION
GLP-1s regulate blood sugar levels by increasing insulin and decreasing glucagon—only when blood sugar levels are high. GLP-1s also improve whole-body energy metabolism by increasing insulin sensitivity of muscle cells and regulating fat cell development.
Get started today
Join thousands of members who have already achieved 15%+ weight loss.
When you join Calibrate, your Medical Team will be with you every step of the way. You’ll kick off your Metabolic Reset with lab work and a Comprehensive Health Intake, followed by a 30-minute, 1:1 video appointment with your Calibrate doctor. Together, you’ll review your lab work and establish a treatment plan—including a prescription to the GLP-1 weight loss medication that’s clinically appropriate for you.
The best part? The Calibrate Medical Team will always be available for support through structured check-ins and in the Medical Channel in the Calibrate app.
Calibrate’s Metabolic Reset is built on decades of research that shows incremental habit change through intensive lifestyle intervention, in combination with medication that works on underlying biology, is the most effective approach for sustained weight loss and improved metabolic health.
Kim Boyd, MD Chief Medical Officer
we navigate insurance for prescription glp-1 medication so you don’t have to
We’re dedicated to finding the best possible coverage for your GLP-1 medication. Our team uses proprietary tools and data to navigate medication coverage and availability. We support our members by:
Communicating with your insurance on your behalf
Exploring every clinically appropriate GLP-1 to find you the most effective, lowest-cost option
Applying relevant patient access programs to help you get affordable coverage, when possible
In the unlikely scenario that we can't help you access a GLP-1 at $25/month or less (after any deductible is met) you'll be eligible for a refund. See more details in our refund policy here.
Frequently Asked Questions
Everything you need to know about prescription weight loss medication and the Calibrate difference.
The medications Calibrate doctors prescribe in our Metabolic Reset are called GLP-1s (glucagon-like peptide-1s). Calibrate doctors prescribe a variety of GLP-1s, including semaglutide, liraglutide, tirzepatide, and dulaglutide. These GLP-1s are often referred to by their brand name, so you may have heard of these medications as Wegovy®, Ozempic®, Mounjaro™, or Saxenda®, to name a few.
All GLP-1s are clinically-tested, stimulant-free, and non-habit forming. GLP-1s address the underlying biology that is most important for weight loss, and help lower your set point, or the weight your body fights to stay at. GLP-1s are powerful, naturally-occurring hormones made by your gut that send signals to your brain to decrease your appetite, improve your metabolic system, and regulate your digestion so you can feel full longer and maximize nutrient absorption.
Regardless of which medication you’re prescribed, our commitment to all of our members remains the same—10% weight loss or your money back (see terms). Plus, if we can’t help you get access to a GLP-1 at $25/month or less you’re eligible for a refund (see details).
At Calibrate we have a team of insurance navigation experts to help you access an initial GLP-1 medication prescription for $25/month or less (after any deductible is met). We’ve helped tens of thousands of members access affordable GLP-1s. However, in the unlikely scenario that there is no path to a low-cost GLP-1 for you, you will be eligible for a refund (less a $250 fee for the initial doctor’s appointment). You will be eligible for this refund after 90 from your doctor’s appointment – the full period of time it may take our team to explore all GLP-1 options for you (though the vast majority of members will get access sooner). See more details in our refund policy here.
Unlike other weight loss medications, GLP-1s address the underlying biology that is most important for weight loss.
Phentermine, for example, is a stimulant (an amphetamine-like analogue) that reduces hunger so that you can more easily deprive yourself of calories—but again, eating less is not a sustainable solution for weight loss. Phentermine can also cause serious side effects including headaches, increased thirst, and significant elevation in blood pressure—which can force your heart to work harder and exacerbate any existing heart conditions.
Contrave, another popular weight loss medication, is a combination of Wellbutrin (a medicine primarily used in the treatment of depression), and naltrexone (a drug used primarily in the prevention of alcohol or opioid abuse). Like phentermine, Contrave helps to reduce appetite, but does not address the most important underlying biology of weight gain.
GLP-1s are FDA-approved, clinically-tested, stimulant-free, and non-habit forming. Not only are they safe, but research shows that they are the most effective medications for sustainable weight loss, especially when combined with lifestyle changes like on Calibrate. GLP-1s are generally very well tolerated, with limited side effects. Many individuals don’t have any side effects at all. However, for those who do, nausea is the most common, and this typically resolves over the first few weeks. In the most recent clinical trials, at the highest dose, less than 5% of people discontinued GLP-1 medications because of side effects. With direct access to your Medical Team for help with titrating and managing side effects through secure messaging, we expect even less difficulty with side effects. Your Medical Team is available throughout the program for any questions about medication side effects or other medical concerns.
Your Calibrate doctor will review your required lab work and entire health history and can answer any questions you might have about medication interactions during your initial video doctor visit. GLP-1s (the medications that Calibrate doctors prescribe) can be safely taken with other common prescription medications—including those for blood pressure, thyroid, and diabetes—and have no contraindications with other prescription or over-the-counter medications.
Calibrate members lose on average 15% of their body weight, per our clinically-reviewed Results Report. You can download the first Calibrate Results Report here.
We're so confident that you'll succeed with Calibrate that we back it up with a money back promise. If you don’t lose at least of 10% your body weight within one year on our Metabolic Reset, you’re eligible for a refund (less the non-refundable $250 cost of the first doctor visit). See terms here.