The medications Calibrate clinicians prescribe in our Metabolic Reset are called GLP-1s (glucagon-like peptide-1s). Calibrate clinicians prescribe a variety of GLP-1s, including semaglutide, liraglutide, tirzepatide, and dulaglutide. These GLP-1s are often referred to by their brand name, so you may have heard of these medications as Wegovy®, Ozempic®, Mounjaro®, or Zepbound®, to name a few.

All GLP-1s are clinically-tested, stimulant-free, and non-habit forming. GLP-1s address the underlying biology that is most important for weight loss, and help lower your set point, or the weight your body fights to stay at. GLP-1s are powerful, naturally-occurring hormones made by your gut that send signals to your brain to decrease your appetite, improve your metabolic system, and regulate your digestion so you can feel full longer and maximize nutrient absorption.

Regardless of which medication you’re prescribed, our commitment to all of our members remains the same—10% weight loss or you're eligible for money back (see terms).

You can read more about GLP-1s here.

At Calibrate we have a team of insurance navigation experts to help you access an initial GLP-1 medication prescription that's typically around $25/month or less (after any deductible is met). We’ve helped tens of thousands of members access affordable GLP-1s. However, in the unlikely scenario that there is no path to a low-cost GLP-1 for you, rest assured we still guarantee results.

Although medication is an important aspect of our program, medical experts agree: the combination of GLP-1 medication and lifestyle changes is the most effective approach to sustainable weight loss. With this in mind, we guarantee that if you stick with Calibrate for 12 consecutive months, you will lose at least 10% of your body weight, with or without the GLP-1 medication or you'll be eligible for money back! (see terms)

Unlike other weight loss medications, GLP-1s address the underlying biology that is most important for weight loss.

Phentermine, for example, is a stimulant (an amphetamine-like analogue) that reduces hunger so that you can more easily deprive yourself of calories—but again, eating less is not a sustainable solution for weight loss. Phentermine can also cause serious side effects including headaches, increased thirst, and significant elevation in blood pressure—which can force your heart to work harder and exacerbate any existing heart conditions. 

Contrave, another popular weight loss medication, is a combination of Wellbutrin (a medicine primarily used in the treatment of depression), and naltrexone (a drug used primarily in the prevention of alcohol or opioid abuse). Like phentermine, Contrave helps to reduce appetite, but does not address the most important underlying biology of weight gain.

GLP-1s are FDA-approved, clinically-tested, stimulant-free, and non-habit forming. Not only are they safe, but research shows that they are the most effective medications for sustainable weight loss, especially when combined with lifestyle changes like on Calibrate. GLP-1s are generally very well tolerated, with limited side effects. Many individuals don’t have any side effects at all. However, for those who do, nausea is the most common, and this typically resolves over the first few weeks. In the most recent clinical trials, at the highest dose, less than 5% of people discontinued GLP-1 medications because of side effects. With direct access to your Medical Team for help with titrating and managing side effects through secure messaging, we expect even less difficulty with side effects. Your Medical Team is available throughout the program for any questions about medication side effects or other medical concerns.

Your Calibrate clinician will review your required lab work and entire health history and can answer any questions you might have about medication interactions during your initial video clinician visit. GLP-1s (the medications that Calibrate clinicians prescribe) can be safely taken with other common prescription medications—including those for blood pressure, thyroid, and diabetes—and have no contraindications with other prescription or over-the-counter medications.

Calibrate members lose on average 16% of their body weight at 12 months and 17% at 24 months, and 19% at 36 months per our clinically-reviewed Results Report. You can download the Calibrate Results Report here.

We're so confident that you'll succeed with Calibrate that we back it up with a money back promise. If you don’t lose at least of 10% your body weight after 12 consecutive months on our program, you'll be eligible for money back (see terms).

GLP-1 medications such as Ozempic®, Wegovy®, and Mounjaro® have been periodically in shortage nationwide since 2021, making it difficult for patients to have consistent access to these medications, or to access them for the first time. We understand it can be concerning to have trouble filling a prescription from your doctor.

Calibrate is fundamentally different from prescription-only services. Medication is just one aspect of our program, and at Calibrate, we use medication as a tool—not the entire treatment. The Calibrate program is built to help your body do the same kind of work that medications like Wegovy® and Saxenda® do, so the best thing you can do if you’re affected by a shortage is to lean into the program. 

Calibrate has helped tens of thousands of members navigate medication shortages, and as our members receive comprehensive support throughout their program: you make a commitment to us, and we make a commitment to supporting you in achieving your goals.

And while we can’t promise uninterrupted medication access (we’re not a manufacturer, a pharmacy, or supplier), we do promise results: 10% weight loss which we back up with a money back promise that applies whether or not our members have ongoing medication access (and we’re the only program to offer this). 

If you can’t access your GLP-1 medication because of a shortage, Calibrate will work with you 1:1 to determine appropriate next steps. To ensure continuity of care, this may include changing to a dose that is currently in stock or finding an alternative GLP-1 medication that is covered by your insurance. 

For more information on medication shortages—as well as helpful tips for anyone experiencing a gap in medication because of a shortage—check out our landing page here.