Calibrate doctors only prescribe GLP-1 medications because research shows, in combination with 1:1 video coaching and small lifestyle changes, they are the safest and most effective long-term option for weight loss.
GLP-1s are different from older classes of weight loss medications (like phentermine) because they work on key underlying metabolic pathways to support sustained weight loss, not a quick fix. Calibrate doctors prescribe a variety of GLP-1 medications, including semaglutide and liraglutide, which you may know under brand names like Wegovy® and Saxenda®.
GLP-1s are clinically proven to reduce inflammation markers, leading to decreased inflammatory response and oxidative stress. CRP (C-reactive protein), a general inflammatory marker, is one marker we may follow during your Metabolic Reset.
SHIFT SET POINT
GLP-1s aid in shifting your body’s set point (the weight your body fights to maintain) by impacting areas in the brain—to help curb cravings, make you feel full faster, and increase your energy expenditure.
GLP-1s slow how quickly food moves from the stomach to the intestines. This helps you feel full for longer by regulating sugar absorption in the intestine.
IMPROVE METABOLIC FUNCTION
GLP-1s regulate blood sugar levels by increasing insulin and decreasing glucagon—only when blood sugar levels are high. GLP-1s also improve whole-body energy metabolism by increasing insulin sensitivity of muscle cells and regulating fat cell development.
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Join thousands of members who have already achieved 15%+ weight loss.
When you join Calibrate, your Medical Team will be with you every step of the way. You’ll kick off your Metabolic Reset with lab work and a Comprehensive Health Intake, followed by a 30-minute, 1:1 video appointment with your Calibrate doctor. Together, you’ll review your lab work and establish a treatment plan—including a prescription to the GLP-1 medication that’s clinically appropriate for you.
The best part? The Calibrate Medical Team will always be available for support through both structured check-ins and in the Medical Channel in the Calibrate app.
Calibrate’s Metabolic Reset is built on decades of research that shows incremental habit change through intensive lifestyle intervention, in combination with medication that works on underlying biology, is the most effective approach for sustained weight loss and improved metabolic health.
Kim Boyd, MD Chief Medical Officer
we navigate insurance so you don’t have to
We’re dedicated to finding the best possible coverage for your GLP-1 medication. Our team uses proprietary tools and data to navigate medication coverage and availability. We support our members by:
Communicating with your insurance on your behalf
Exploring every clinically appropriate GLP-1 to find you the most effective, lowest-cost option
Applying relevant patient access programs to help you get affordable coverage, when possible
GLP-1s are FDA-approved, clinically-tested, stimulant-free, and non-habit forming. They are generally very well tolerated, with limited side effects. Many individuals don’t have any side effects at all. However, for those who do, nausea is the most common, and this typically resolves over the first few weeks. In the most recent clinical trials, at the highest dose, less than 5% of people discontinued GLP-1 medications because of side effects. With direct access to your Medical Team for help with titrating and managing side effects through secure messaging, we expect even less difficulty with side effects. Your Medical Team is available throughout the program for any questions about medication side effects or other medical concerns.
Unlike other weight loss medications, GLP-1s address the underlying biology that is most important for weight loss.
Phentermine, for example, is a stimulant (an amphetamine-like analogue) that reduces hunger so that you can more easily deprive yourself of calories—but again, eating less is not a sustainable solution for weight loss. Phentermine can also cause serious side effects including headaches, increased thirst, and significant elevation in blood pressure—which can force your heart to work harder and exacerbate any existing heart conditions.
Contrave, another popular weight loss medication, is a combination of Wellbutrin (a medicine primarily used in the treatment of depression), and naltrexone (a drug used primarily in the prevention of alcohol or opioid abuse). Like phentermine, Contrave helps to reduce appetite, but does not address the most important underlying biology of weight gain.
While an injection may sound scary, most members actually report injections being painless, quick, and easy. (It’s just under the skin—going into your fat instead of your muscle. The needle is ultra-fine, so it isn’t like a typical shot.) GLP-1s are self-administered either daily or weekly depending on the medication. Your Calibrate doctor can walk you through how this works and can also send you a short video to help. In addition, not only are injectables the medications we prescribe more effective, but they also have fewer and safer side effects than other weight loss medications.
Your Calibrate doctor will use your medical history and insurance coverage to prescribe the best GLP-1 for you and may prescribe you an oral GLP-1 option if injections are not a good fit. The Calibrate Medical Team is available to answer your questions about GLP-1s and to address other medical concerns you might have throughout your Calibrate year.
Your Calibrate doctor will review your required lab work and entire health history and can answer any questions you might have about medication interactions during your initial video doctor visit. GLP-1s (the medications that Calibrate doctors prescribe) can be safely taken with other common prescription medications—including those for blood pressure, thyroid, and diabetes—and have no contraindications with other prescription or over-the-counter medications.
Our first cohort of members lost an average of 15% of their body weight. You can download the first Calibrate Results Report here.
Our Results Guarantee states that eligible members are guaranteed a minimum of 10% weight loss within one year on the Calibrate One-Year Metabolic Reset, or they’re eligible for a refund (the cost of the program minus the cost of your Metabolic Health Assessment, see terms). We think you’d be thrilled with your results.