Calibrate doctors only prescribe GLP-1 medications (like Ozempic®, Wegovy®, and Mounjaro®) because research shows, in combination with 1:1 video coaching and lifestyle changes, they are the most effective for weight loss.
GLP-1s are different from older classes of prescription weight loss medications (like phentermine) because they work on key underlying metabolic pathways to support sustained weight loss. They're not just another quick fix. Calibrate doctors prescribe a variety of GLP-1 medications, including semaglutide and liraglutide, which you may know under brand names like Wegovy®, Saxenda®, Ozempic®, or Mounjaro®.
GLP-1s are clinically proven to reduce inflammation markers, leading to decreased inflammatory response and oxidative stress. CRP (C-reactive protein), a general inflammatory marker, is one marker we may follow during your Metabolic Reset.
SHIFT SET POINT
GLP-1s aid in shifting your body’s set point (the weight your body fights to maintain) by impacting areas in the brain—to help curb cravings, make you feel full faster, and increase your energy expenditure.
GLP-1s slow how quickly food moves from the stomach to the intestines. This helps you feel full for longer by regulating sugar absorption in the intestine.
IMPROVE METABOLIC FUNCTION
GLP-1s regulate blood sugar levels by increasing insulin and decreasing glucagon—only when blood sugar levels are high. GLP-1s also improve whole-body energy metabolism by increasing insulin sensitivity of muscle cells and regulating fat cell development.
Get started today
Join thousands of members who have already achieved 15% weight loss on average with Calibrate's holistic program.
Calibrate doctors prescribe Glucagon-like Peptide-1 Receptor Agonists, GLP-1s for short—because research shows that when combined with lifestyle changes, they're the safest and most effective approach to achieve sustainable weight loss.
Your Calibrate Medical Team determines which medication is clinically appropriate for you. GLP-1 and combined GLP-1/GIP medications work on your body’s own receptors to decrease appetite, increase satiety, and regulate insulin and glucose. Calibrate’s approach combines our research-backed behavior change program with medications in the GLP-1 category (because they are proven to be most effective for metabolic health and weight loss), which enhance each other.
A once-weekly injectable GLP-1 indicated for the treatment of overweight and obesity.
A once-weekly injectable medication that works similarly to the other drugs in the GLP-1 family, but is also an agonist for a second peptide hormone called GIP. It is indicated for the treatment of Type 2 diabetes, and is safe and effective for weight loss.
Rybelsus® is a pill—not an injection. It's the only oral GLP-1 medication currently on the market, and is taken daily. Rybelsus® is indicated for the treatment of Type 2 diabetes, and is safe and effective for weight loss.
When you join Calibrate, your Medical Team will be with you every step of the way. You’ll kick off your Metabolic Reset with lab work and a Comprehensive Health Intake, followed by a 30-minute, 1:1 video appointment with your Calibrate doctor. Together, you’ll review your lab work and establish a treatment plan—including a prescription to the GLP-1 weight loss medication that’s clinically appropriate for you.
The best part? The Calibrate Medical Team will always be available for support through structured check-ins and in the Medical Channel in the Calibrate app.
Calibrate’s Metabolic Reset is built on decades of research that shows incremental habit change through intensive lifestyle intervention, in combination with medication that works on underlying biology, is the most effective approach for sustained weight loss and improved metabolic health.
Kim Boyd, MD Chief Medical Officer
Frequently Asked Questions
Everything you need to know about prescription weight loss medication and the Calibrate difference.
The medications Calibrate doctors prescribe in our Metabolic Reset are called GLP-1s (glucagon-like peptide-1s). Calibrate doctors prescribe a variety of GLP-1s, including semaglutide, liraglutide, tirzepatide, and dulaglutide. These GLP-1s are often referred to by their brand name, so you may have heard of these medications as Wegovy®, Ozempic®, Mounjaro™, or Saxenda®, to name a few.
All GLP-1s are clinically-tested, stimulant-free, and non-habit forming. GLP-1s address the underlying biology that is most important for weight loss, and help lower your set point, or the weight your body fights to stay at. GLP-1s are powerful, naturally-occurring hormones made by your gut that send signals to your brain to decrease your appetite, improve your metabolic system, and regulate your digestion so you can feel full longer and maximize nutrient absorption.
Regardless of which medication you’re prescribed, our commitment to all of our members remains the same—10% weight loss or your money back (see terms). Plus, if we can’t help you get access to a GLP-1 at $25/month or less you’re eligible for a refund (see details).
At Calibrate we have a team of insurance navigation experts to help you access an initial GLP-1 medication prescription for $25/month or less (after any deductible is met). We’ve helped tens of thousands of members access affordable GLP-1s. However, in the unlikely scenario that there is no path to a low-cost GLP-1 for you, you will be eligible for a refund (less a $250 fee for the initial doctor’s appointment). You will be eligible for this refund after 90 days from your doctor’s appointment – the full period of time it may take our team to explore all GLP-1 options for you (though the vast majority of members will get access sooner). See more details in our Refund Policy here.
Unlike other weight loss medications, GLP-1s address the underlying biology that is most important for weight loss.
Phentermine, for example, is a stimulant (an amphetamine-like analogue) that reduces hunger so that you can more easily deprive yourself of calories—but again, eating less is not a sustainable solution for weight loss. Phentermine can also cause serious side effects including headaches, increased thirst, and significant elevation in blood pressure—which can force your heart to work harder and exacerbate any existing heart conditions.
Contrave, another popular weight loss medication, is a combination of Wellbutrin (a medicine primarily used in the treatment of depression), and naltrexone (a drug used primarily in the prevention of alcohol or opioid abuse). Like phentermine, Contrave helps to reduce appetite, but does not address the most important underlying biology of weight gain.
GLP-1s are FDA-approved, clinically-tested, stimulant-free, and non-habit forming. Not only are they safe, but research shows that they are the most effective medications for sustainable weight loss, especially when combined with lifestyle changes like on Calibrate. GLP-1s are generally very well tolerated, with limited side effects. Many individuals don’t have any side effects at all. However, for those who do, nausea is the most common, and this typically resolves over the first few weeks. In the most recent clinical trials, at the highest dose, less than 5% of people discontinued GLP-1 medications because of side effects. With direct access to your Medical Team for help with titrating and managing side effects through secure messaging, we expect even less difficulty with side effects. Your Medical Team is available throughout the program for any questions about medication side effects or other medical concerns.
Your Calibrate doctor will review your required lab work and entire health history and can answer any questions you might have about medication interactions during your initial video doctor visit. GLP-1s (the medications that Calibrate doctors prescribe) can be safely taken with other common prescription medications—including those for blood pressure, thyroid, and diabetes—and have no contraindications with other prescription or over-the-counter medications.
Calibrate members lose on average 15% of their body weight, per our clinically-reviewed Results Report. You can download the Calibrate Results Report here.
We're so confident that you'll succeed with Calibrate that we back it up with a money back promise. If you don’t lose at least of 10% your body weight within one year on our Metabolic Reset, you’re eligible for a refund (less the non-refundable $250 cost of the first doctor visit). See terms here.
Calibrate is committed to helping members receive medication as quickly as possible, whether it’s their initial prescription or subsequent refills. Our team’s expertise spans data, pharmacy operations, medication coverage, patient access programs, insurance forms, and communicating directly with pharmacies. We have helped tens of thousands of members secure access to GLP-1s, and even amid inventory issues, we can provide members the best possible chance at getting GLP-1 access today.
Our team monitors nationwide inventory for all FDA-approved GLP-1 medications. Given the demand for GLP-1s and the time it takes to secure access, the sooner you join Calibrate, the sooner our team can start helping you obtain your doctor-prescribed GLP-1 medication.
Once you sign up for Calibrate, you complete our Orientation phase, which includes getting lab work done ahead of your doctor visit, where you will be prescribed a GLP-1 as clinically appropriate. Since this process can take a few weeks, by signing up now, you are putting yourself in the best position to get GLP-1 access as soon as possible.
Regardless of GLP-1 access, with Calibrate’s holistic program we’re confident you will achieve real results, and our promise is the same regardless of medication access: 10% weight loss or your money back.