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medication that drives weight loss

Calibrate doctors prescribe GLP-1 medications because research shows, in combination with 1:1 video coaching and small lifestyle changes, they are the safest and most effective long-term option for weight loss.

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GLP-1 Medications Fight Weight With Biology

GLP-1s are different from older classes of prescription weight loss medications (like phentermine) because they work on key underlying metabolic pathways to support sustained weight loss. They're not just another quick fix. Calibrate doctors prescribe a variety of GLP-1 medications, including semaglutide and liraglutide, which you may know under brand names like Wegovy®, Saxenda®, Ozempic®, or Mounjaro®.


GLP-1s are clinically proven to reduce inflammation markers, leading to decreased inflammatory response and oxidative stress. CRP (C-reactive protein), a general inflammatory marker, is one marker we may follow during your Metabolic Reset.


GLP-1s aid in shifting your body’s set point (the weight your body fights to maintain) by impacting areas in the brain—to help curb cravings, make you feel full faster, and increase your energy expenditure.


GLP-1s slow how quickly food moves from the stomach to the intestines. This helps you feel full for longer by regulating sugar absorption in the intestine.


GLP-1s regulate blood sugar levels by increasing insulin and decreasing glucagon—only when blood sugar levels are high. GLP-1s also improve whole-body energy metabolism by increasing insulin sensitivity of muscle cells and regulating fat cell development.

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Join thousands of members who have already achieved 15%+ weight loss.

Michele Griffith, MD

Real doctors.
Not Bots.

When you join Calibrate, your Medical Team will be with you every step of the way. You’ll kick off your Metabolic Reset with lab work and a Comprehensive Health Intake, followed by a 30-minute, 1:1 video appointment with your Calibrate doctor. Together, you’ll review your lab work and establish a treatment plan—including a prescription to the GLP-1 weight loss medication that’s clinically appropriate for you.

The best part? The Calibrate Medical Team will always be available for support through structured check-ins and in the Medical Channel in the Calibrate app.

the calibrate difference

There’s a reason 93% of members say Calibrate is the most effective program they’ve tried. Join and achieve 10%+ weight loss, guaranteed, or get your money back (see terms).

Calibrate’s Metabolic Reset is built on decades of research that shows incremental habit change through intensive lifestyle intervention, in combination with medication that works on underlying biology, is the most effective approach for sustained weight loss and improved metabolic health.

Kim Boyd, MD Chief Medical Officer

we navigate insurance for prescription glp-1 medication so you don’t have to

We’re dedicated to finding the best possible coverage for your GLP-1 medication. Our team uses proprietary tools and data to navigate medication coverage and availability. We support our members by:

  • Communicating with your insurance on your behalf
  • Exploring every clinically appropriate GLP-1 to find you the most effective, lowest-cost option
  • Applying relevant patient access programs to help you get affordable coverage, when possible

In the unlikely scenario that we can't help you access a GLP-1 at $25/month or less (after any deductible is met) you'll be eligible for a refund. See more details in our refund policy here

Frequently Asked Questions

Everything you need to know about prescription weight loss medication and the Calibrate difference.